| 摘要: |
| 目的：观察何氏养肾方治疗尿酸性肾病的临床疗效。方法：将60例尿酸性肾病患者随机分为治疗组与对照组，每组各30例。2组患者均进行常规治疗，治疗组在常规治疗基础上服用何氏养肾方颗粒治疗，对照组在常规治疗基础上服用别嘌醇片和氯沙坦钾片治疗。治疗3个月后比较2组综合疗效及肾功能各项指标的变化。结果：总有效率治疗组为83.33%，对照组为75.00%，2组比较，差异有统计学意义（P＜0.05）；治疗组血尿酸、尿β2微球蛋白、24h尿蛋白定量、尿白蛋白肌酐比值治疗前后比较，差异均有统计学意义（P＜0.05）；对照组血尿酸、24h尿蛋白定量、尿白蛋白肌酐比值治疗前后比较，差异均有统计学意义（P＜0.05）；2组治疗后尿β2微球蛋白、血胱抑素C、24h尿蛋白定量、尿白蛋白肌酐比值比较，差异有统计学意义（P＜0.05）。结论：何氏养肾方不但能治疗尿酸性肾病，还可预防尿酸性肾病向肾衰竭发展，且无明显毒副作用。 |
| 关键词: 尿酸性肾病 中医药疗法 何氏养肾方 |
| DOI： |
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| Clinical effect of He’s Yangshen prescription in treatment of uric acid nephropathy：An analysis of 30 cases |
| ZHONG Yunliang,DENG Li’e,GUO Huifang |
| (Dongguan Traditional Chinese Medicine Hospital，Dongguan 523000，Guangdong，China) |
| Abstract: |
| Objective：To investigate the clinical effect of He’s Yangshen prescription in the treatment of uric acid nephropathy.Methods：A total of 60 patients with uric acid nephropathy were randomly divided into treatment group and control group，with 30 patients in each group.In addition to conventional treatment，the patients in the treatment group were given the granules of He’s Yangshen prescription，and those in the control group were given allopurinol tablets and losartan potassium tablets.The two groups were compared in terms of overall response and the change in renal function parameters after 3 months of treatment.Results：There was a significant difference in overall response rate between the treatment group and the control group (83.33% vs 75.00%，P<0.05).After treatment，the treatment group had significant changes in serum uric acid，urinary β2-microglobulin，24-hour urinary protein，and urinary albumin-to-creatinine ratio (P<0.05)，and the control group had significant changes in serum uric acid，24-hour urinary protein，and urinary albumin-to-creatinine ratio (P<0.05).There were significant differences between the two groups in urinary β2-microglobulin，cystatin C，24-hour urinary protein，and urinary albumin-to-creatinine ratio after treatment (P<0.05).Conclusion：He’s Yangshen prescription exerts a therapeutic effect on uric acid nephropathy and can prevent its progression to liver failure，with no marked toxic and side effects. |
| Key words: uric acid nephropathy traditional Chinese medicine treatment He’s Yangshen prescription |
