| 摘要: |
| 目的：探讨促精宝汤治疗弱精症的临床疗效及其作用机制。方法：将131例弱精症患者随机分为2组，治疗组65例采用促精宝汤治疗，对照组66例采用复方玄驹胶囊治疗。结果：总有效率治疗组为90.8%，对照组为81.8%，组间比较，差异有统计学意义（P<0.05）；治疗组在改善患者精液量、精子密度、精子活率、a级精子和b级精子、精浆超氧化物歧化酶同工酶（SOD）、丙二醛（MDA）、一氧化氮（NO）含量等方面均明显优于对照组，差异均有统计学意义（P<0.05）。结论：促精宝汤治疗弱精症的临床疗效显著，其作用机制可能与提高SOD含量、降低MDA与NO的表达有关。 |
| 关键词: 弱精症 中医药疗法 促精宝汤 |
| DOI： |
|
|
| Clinical effect of Cujingbao decoction in treatment of asthenozoospermia：An analysis of 65 cases |
| YUAN Yuan，,WANG Zhong-min，,WANG Zun-lai |
| (Tianjin Beichen Beimen Hospital，Tianjin 300400，China;Tianjin Beichen Hospital，Tianjin 300400，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Cujingbao decoction in the treatment of asthenozoospermia and its mechanism of action.Methods：A total of 131 patients with asthenozoospermia were divided into treatment group with 65 patients and control group with 66 patients.The patients in the treatment group were given Cujingbao decoction，and those in the control group were given compound Xuanju capsules.Results：There was a significant difference in overall response rate between the treatment group and the control group (90.8% vs 81.8%，P<0.05).Compared with the control group，the treatment group had significantly greater improvements in semen volume，sperm density，sperm motility rate，the numbers of grade A and B sperms，and the content of superoxide dismutase (SOD)，malondialdehyde (MDA)，and nitric oxide(NO)in seminal plasma(P<0.05).Conclusion：Cujingbao decoction has a marked clinical effect in the treatment of asthenozoospermia，possibly by increasing the content of SOD and reducing the expression of MDA and NO. |
| Key words: asthenozoospermia traditional Chinese medicine treatment Cujingbao decoction |
