| 摘要: |
| 目的：观察扶正消癌方对结直肠癌（CRC）根治术后患者的环氧化酶-2（COX-2）和组织蛋白酶D（Cathepsin-D）的影响。方法：将结直肠癌根治术后患者100例按随机数字表法分为2组各50例，2组均采用FOLFOX4方案治疗后，治疗组予扶正消癌方治疗，对照组予香菇多糖片治疗。结果：治疗组Cathepsin-D活性治疗前后组内比较及治疗后组间比较，2组COX-2水平治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P<0.05）。结论：扶正消癌方能够降低结直肠癌根治术后患者Cathepsin-D和COX-2的表达水平，表明抗肿瘤血管生成可能是扶正消癌方抑制肿瘤进展的主要作用机制之一。 |
| 关键词: 结直肠癌根治术后 中医药疗法 扶正消癌方 Cathepsin-D COX-2 |
| DOI： |
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| Effect of Fuzheng Xiaoai prescription on cyclooxygenase-2 and cathepsin-D in patients after radical treatment of colorectal cancer |
| PENG Zhuo-yu，,CHEN Jing，,LI Rui-sheng， |
| (The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，Guangxi，China;Guangxi University of Chinese Medicine，Nanning 530001，Guangxi，China) |
| Abstract: |
| Objective：To investigate the effect of Fuzheng Xiaoai prescription on cyclooxygenase-2（COX-2）and cathepsin-D in patients after radical treatment of colorectal cancer（CRC).Methods：A total of 100 patients who underwent radical treatment of CRC were divided into treatment group and control group using a random number table，with 50 patients in each group.After treatment with the FOLFOX4 regimen，the patients in the treatment group were given Fuzheng Xiaoai prescription，and those in the control group were given lentinan tablets.Results：After treatment，the treatment group had significant changes in cathepsin-D activity and COX-2 level，and there were significant differences between the two groups（P<0.05).Conclusion：Fuzheng Xiaoai prescription can reduce the levels of cathepsin-D and COX-2 in patients after radical treatment of CRC，suggesting that anti-tumor angiogenesis may be one of the mechanisms of action of Fuzheng Xiaoai prescription in inhibiting tumor progression. |
| Key words: after radical treatment of colorectal cancer traditional Chinese medicine treatment Fuzheng Xiaoai prescription cathepsin-D cyclooxygenase-2 |
